The 13-valent vaccine, mostly referred to as the 13-valent pneumococcal polysaccharide conjugate vaccine, can be used to take fever-reducing medication if you develop a fever with a temperature greater than 38.5 degrees. The main purpose of the 13-valent pneumococcal conjugate vaccine is to prevent invasive diseases caused by pneumococcus and serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F. Vaccination may cause redness, swelling and pain at the site of vaccination, and may also cause fever and other adverse reactions. If the fever is low, most of them will recover on their own without special treatment; if the temperature is greater than 38.5 degrees, you can take antipyretic medication under the guidance of a doctor or pharmacist to relieve the symptoms with symptomatic treatment. Before vaccination, you need to know the contraindications of vaccination, and after vaccination, you need to observe for half an hour at the vaccination site. Injection of 13-valent pneumococcal polysaccharide conjugate vaccine, if there are serious adverse reactions, or adverse reactions continue for more than 3 days without relief, it is recommended to consult a doctor in a timely manner, the drug needs to be used under the guidance of a professional doctor, to avoid abusing the drug by themselves.