Hepatitis B major triple positive and minor triple positive can not be directly judged which is more serious, generally the major triple positive is more infectious and the condition progresses faster, the minor triple positive is relatively less infectious and the condition progresses slower. However, minor triple positive may still have liver damage, leading to cirrhosis and liver cancer, which needs to be emphasized. Hepatitis B triple positive and small triple positive mainly refers to the two hepatitis B two half markers are different, hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), hepatitis B e antigen (HBeAg), hepatitis B e antibody (HBeAb), hepatitis B core antibody (HBcAb) of which 1, 3, 5 were positive for triple positive, 1, 4, 5 were positive for small triple positive. It is generally believed that when big triple positive, hepatitis B virus is active and highly infectious; when small triple positive, although e antibody is produced, but if hepatitis B virus DNA load is high and liver function is not good also suggests that the hepatitis B virus is active, if necessary, use interferon and other medications under the guidance of the doctor, to avoid the condition from deteriorating and leading to cirrhosis and liver cancer. Therefore, the severity of Hepatitis B cannot be judged solely on the basis of whether Hepatitis B is triple positive or triple positive, but also needs to be combined with a comprehensive assessment based on liver function, ultrasound, and Hepatitis B viral DNA load.