The main treatment is surgery. Different treatment options are available according to different conditions: 1. Peripheral intrahepatic bile duct stones without obvious symptoms do not require surgical treatment. 2, left lobe of the liver bile duct stones, extrahepatic bile duct without dilatation and stones, it is appropriate to perform left outer lobe of the liver resection, protect and reveal the confluence of the left outer lobe of the bile duct, and remove the left inner lobe of the bile duct stones through the confluence, and then repair the bile duct of the confluence. It is not necessary to explore the common bile duct. 3. In cases of combined common hepatic duct stones and bile duct dilatation, the common bile duct is explored and the stones are removed. Intraoperative choledochoscopy is used to retrieve the stone, and Fogarty catheter can also be used to retrieve the intrahepatic bile duct stone and leave a suitable T-tube for drainage. Ultrasound and T-tube imaging are performed half a month after surgery to determine if there are any stones left. If there is, the stone should be removed by choledochoscopy 6 weeks after the surgery. 4.In case of combined hilar bile duct (grade 1) stenosis, the right and left hilar ducts should be revealed intraoperatively, the stenosis should be incised, the stenosis should be released, the stone should be removed, and Roux-en-Y anastomosis of hilar bile duct jejunum should be performed, and the gallbladder should be removed at the same time. 5.If the right half of the intrahepatic bile duct stone combined with hepatic atrophy, but the left half of the liver is normal, the right half of the atrophied liver can be removed. 6.If the whole intrahepatic bile duct is full of stones, which cannot be removed at all, and the liver function is damaged with life threatening, liver transplantation can be considered. 7.In case of combined intrahepatic cholangitis, antibiotics should be actively applied to control the infection. In case of severe infection, surgical exploration of the bile duct should also be performed to release the obstruction, remove the stone and drainage treatment, or remove the lesion at the same time if conditions permit. Various treatments for intrahepatic bile duct stones are not yet fully satisfactory, mainly because of the high residual rate of stones and the high rate of reoperation, which is more difficult to treat than extrahepatic bile duct stones and should not be underestimated!