Finding no change in the primary lesion depends on the nature, location, and size of the metastatic lesion, as well as its current major impact on the body. If the tumor is relatively small, radical surgical resection can be done to treat the current metastasis, and the primary lesion may be re-exposed 1 month, 2 months, or 1 year later. If the metastatic foci are relatively large and have obvious compression or impact on the body, palliative radiotherapy as well as systemic chemotherapy can be done. At this time, it is necessary to do puncture biopsy of the metastatic foci in order to clarify the nature of the pathology and to speculate the site of the primary foci based on the hints of immunohistochemistry. Of course, the location of the primary focus does not affect the treatment of the metastases, but mainly according to the pathological nature of the metastases to do the corresponding treatment, such as radiotherapy, chemotherapy.