Generally, if you use ibuprofen extended-release tablets, you can take another one at an interval of 12 hours. It is important to note that since ibuprofen extended-release tablets are an extended-release dosage form, they must not be broken, broken up, or chewed while in use, but must be taken whole with warm water. In order to reduce the possible gastrointestinal adverse reactions caused by ibuprofen extended-release tablets, it is recommended to use them 15-30 minutes after meals, and not to drink alcohol or use alcoholic beverages at the same time when using ibuprofen extended-release tablets. In addition, other drugs with antipyretic and analgesic ingredients such as acetaminophen, celecoxib, diclofenac sodium, etc. should not be used at the same time when using Ibuprofen extended-release tablets, and the drug must be used in strict accordance with the instructions for use or doctor’s prescription.