Hepatitis B surface antigen cannot turn negative, interferon can be stopped for a period of time. 1. The treatment course of interferon is usually 1 year, and the surface antigen has been decreasing but not yet turned negative, the course of treatment can be extended. 2. After 3 months, the surface antigen has not decreased significantly (minor triple Yang), can be reviewed after another month, still no decrease. Consideration may be given to stopping the drug temporarily. 3. Due to its side effects, it is impossible to use interferon for a long time and for life, at present, there is a kind of “pulse therapy” program: for those who have the effect, but the effect is not obvious, you can stop the drug temporarily, and continue to use it at intervals, so that the course of treatment is not limited to 1-2 years. 4. After turning negative: after turning negative, there is still the possibility of surface antigen reappearance. Therefore, after the surface antigen disappears, if you can still tolerate the side effects, you can consolidate 4-12 injections. In addition, I advocate interferon combined with oral antiviral drugs, stop interferon, continue to take oral antiviral drugs for six months to one year, can still be maintained as surface antigen-negative, and then stop oral antiviral drugs.