Helicobacter pylori is accurately called Helicobacter pylori, and the treatment is often clinically quadruple therapy. H. pylori infection often occurs in the stomach and duodenum, and is a high-risk factor for a variety of gastrointestinal diseases. Quadruple therapy is a combination of 1 acid suppressant + 2 antibiotics + 1 bismuth preparation, which is a common clinical method used to treat H. pylori infection. Acid suppressant is usually used omeprazole, rabeprazole, pantoprazole and other drugs, antibiotics are commonly used clarithromycin, amoxicillin, metronidazole or quinolones, etc., and bismuth preparation is commonly used bismuth potassium citrate, colloidal bismuth pectin and other drugs. The treatment process should be carried out under the guidance of a physician, not blindly self-medication, the existence of allergies to therapeutic drugs need to inform the physician in a timely manner, so as to facilitate the adjustment of medication.