Introduction: those Chinese medicines that are contraindicated to be combined with antibiotics. With the popularity of the combination of Chinese and Western medicine in the treatment of diseases, its compounding should also be strictly mastered. The irrational compounding not only affects the therapeutic effect, but also produces toxic side effects, the following Chinese medicines should not be used in combination with antibiotics. Dragon bone, pearl, oyster, cuttlebone, etc. contain calcium, easy to form chelates with tetracycline antibiotics to affect the absorption and reduce the efficacy. Blood Yu charcoal, Ai Ye charcoal, calcined tile fern has a strong adsorption power, which can reduce the absorption of antibiotics in the gastrointestinal tract. Shenqu, malt contains a variety of digestive enzymes, some antibiotics make its activity inhibited, weakening its function of elimination of food and stomach. Gypsum, hematite, talc containing magnesium, aluminum, iron ions and tetracycline antibiotics, the formation of chelates and reduce the efficacy. Xuanhu, mast, licorice, etc. inhibit gastric acid secretion, affecting the absorption of tetracycline, tetracycline, yellow medicinal herbs can damage the liver, and tetracycline combined with the increase in toxic effects. Schisandra, hawthorn, umeboshi can acidify the urine, so that the alkaline tetracycline, erythromycin efficacy is reduced. Ginger, gentian, rosmarinus officinalis, etc. promote gastric acid secretion, erythromycin destruction increased. Belladonna herbs inhibit peristalsis, delay gastric emptying, erythromycin in the stomach to stay longer, increased destruction. The tannins contained in ground elm, thuja, pomegranate peel, etc. can combine with erythromycin and impede erythromycin absorption. Chinese medicine laxatives such as croton, black and white ugly can accelerate the passage of erythromycin through the intestinal tract, affecting its absorption. Rhinoceros horn, pearl contained protein and its hydrolysis products (a variety of amino acids), can resist the bacteriostatic effect of safranin and reduce the efficacy. Yin Chen has antagonistic effect on the antibacterial effect of chloramphenicol and can reduce the efficacy of chloramphenicol. Containing tannin in traditional Chinese medicine, such as quintuple seed, chebula, pomegranate bark, ground elm, jujube bark, four seasons, rhubarb, etc. and ashwagandha, mycotoxin, lincomycin, etc. when taken with the same dose, it can be combined into tannate precipitation, which is not easy to be absorbed. Alkaline herbal borax and amino acid glycoside antibiotics such as streptomycin, kanamycin, gentamicin, neomycin, tobramycin taken at the same time, can increase the toxic side effects. When borax is used with weakly acidic furadantin, penicillin and vanguardin, it can reduce the reabsorption of these drugs and lower the blood concentration.