High creatinine means our kidneys have been damaged, and the higher the creatinine is, the more serious the kidney damage is. In fact, high creatinine can be completely prevented and controlled by staying away from the main causes that trigger high creatinine. Once high creatinine is detected, it must be treated in time. So, what exactly are the causes of high creatinine? 1, life is overworked, excessive physical exertion, excessive intercourse, consumption of energy, will also cause the body creatinine to rise. 2, hypertensive patients, long-term hypertension, continued heavy proteinuria, the condition is not timely control, the disease process will be accompanied by high creatinine phenomenon. 3, the body sweats a lot, drink less water, the increase in urine volume will lead to blood concentration, blood concentration increases, may trigger the creatinine elevation. 4, patients taking drugs that are more harmful to the body, especially kidney disease patients taking drugs that are more harmful to the kidneys, will lead to an increase in the body’s creatinine. 5, kidney disease patients, especially patients with renal insufficiency, kidney lesions, serious damage to the glomerulus, the filtration of blood creatinine seriously reduced, will lead to a large number of body blood creatinine can not be excreted through the urine, resulting in high creatinine. Currently this is the main cause of high creatinine and must be treated in a timely manner.