Creatinine value of uremia should be >707μmol/L, but creatinine level is affected by many factors, and nowadays, the definition of uremia is mostly promoted clinically with glomerular filtration rate <10ml/min. Renal insufficiency can be divided into four stages, and different creatinine value levels correspond to different periods. Uremia creatinine value >707μmol/L belongs to the stage of end-stage renal disease. Elevated blood creatinine in the uremic stage represents renal function impairment of at least >2/3, but creatinine is a muscle metabolite and is easily affected by muscle volume, patient age, weight, and gender. Therefore, the renal function situation can vary greatly in patients with different muscle volumes, even if the blood creatinine levels are the same. The use of glomerular filtration rate for chronic kidney disease staging is currently preferred, and a glomerular filtration rate <10 ml/min is usually defined as uremic syndrome. Once uremia occurs, the preferred treatment is dialysis therapy, but long-term dialysis can cause heart failure and osteoporosis. Therefore, renal transplantation therapy is also an important option for patients with end-stage renal failure.