Creatinine 400μmol/L is not uremia, when the creatinine value exceeds 707μmol/L, it only indicates the development of the disease to uremia. There are many clinical causes of elevated creatinine, such as chronic nephritis, diabetic nephropathy, hypertensive kidney damage, etc. These kidney diseases develop to the final stage of uremia, so it is necessary to avoid deterioration of the disease through active medication and life diet regimen in the early stage of kidney disease. The value of blood creatinine can reflect the good or bad kidney function, when there is a slight high blood creatinine, we should pay enough attention to it. By identifying the cause of the disease and adjusting the treatment plan, we can prevent the deterioration of the disease. Once the kidney disease develops to the stage of uremia, dialysis treatment should be started.