Coronary artery disease and uremia are two different diseases with different pathogenesis, and they affect each other in the process of disease development, making the disease worse. Coronary artery disease is an atherosclerotic heart disease, the intima-media lipid deposits form plaque, blocking the blood vessels causing myocardial cell ischemia or myocardial cell necrosis, clinical manifestations of angina pectoris or myocardial infarction. Uremia is a chronic kidney disease and is the most severe type of advanced renal failure. Due to the complete loss of kidney function, the accumulation of toxins in the body, as well as water and sodium retention, increased blood pressure, lipid metabolism disorders, renal anemia, etc. will aggravate the condition of patients with coronary heart disease, heart overload complicating heart failure and arrhythmias, and its prognosis is poor and mortality is high.