Advanced pancreatic cancer can be relieved by different drugs according to the severity of pain. 1. Mild pain: mild pain can be treated with non-steroidal anti-inflammatory drugs, such as common aspirin with certain antipyretic, analgesic and anti-inflammatory effects, and ibuprofen with its low incidence of adverse reactions, which belongs to the first-order painkillers. However, it has certain gastrointestinal reactions and skin reactions with certain kidney damage. 2. Moderate to severe pain: opioids can be used, mainly morphine-based analgesic drugs, including a variety of slow-release tablets, controlled-release tablets, etc., its analgesic effect on most of the acute pain and chronic pain is good, the role of persistent chronic dull pain is greater than intermittent sharp pain, but the effect of neuropathic pain is poor. However, it should not be used in excess to avoid inducing adverse reactions such as morphine toxicity.