Papillomatosis is not a cancer, and there is no medical evidence that it is a precancerous lesion. It is sometimes difficult to distinguish papilloma from papillary carcinoma clinically. Papilloma is a tumor of epithelial origin, and its pathological characteristics are high proliferation of epithelial tissue, overgrowth of squamous epithelium outwardly to form papillae, which are round or oval lumps with loose and pulsatile connective tissues in the center, and papilloma often occurs in the nasal cavity, external auditory canal, pharynx, esophagus, mammary gland and other tissues, and it is mostly benign tumor, and can be diagnosed clearly according to the typical clinical manifestations combined with endoscopic and pathological examinations. Most of them are benign tumors and can be diagnosed clearly according to typical clinical manifestations, combined with endoscopy and pathological examination. Surgical treatment is the mainstay, and the operation should be thorough, and the normal tissues around the base and infiltrated tissues should be removed to the safety limit.