Patients with advanced kidney cancer presenting with blood in urine can be treated by surgery as well as postoperative adjuvant targeted drugs. Kidney cancer is one of the common malignant tumors in urinary system, and the most common kidney cancer in clinic is renal clear cell carcinoma. Its clinical manifestations are typical hematuria, pain and mass. In early stage, hematuria is painless hematochezia, and in late stage, it is hematochezia with lumbar cramps. For the treatment of advanced kidney cancer patients, the current comprehensive treatment program is mainly based on surgery. The choice of surgery is mostly radical nephrectomy. However, for advanced kidney cancer, most of the patients have lost the chance of surgical resection, they can consider using targeted therapy drugs or immunotherapy drugs, which can generally control the tumor progression and improve the prognosis of the patients.Targeted therapy mainly includes sunitinib, sorafenib, axitinib, bevacizumab and so on, while immunotherapy includes natalizumab combined with ipilizumab and leukocidin, etc. If there is severe hematuria, it can also be used as a comprehensive treatment plan. If severe hematuria exists, embolization can also be performed to stop bleeding through interventional therapy and so on. The medication used for kidney cancer is related to pathological subtype and stage, etc. It is recommended to go to regular hospitals to evaluate the condition and follow the doctor’s instruction to cooperate with the treatment, and follow the doctor’s instruction strictly for drug treatment.