Low-grade fever after shingles vaccination can be handled in different ways depending on the mental state, including drinking plenty of fluids, resting and administering antipyretic medication, among others. The shingles vaccine, as a biological agent, may cause adverse reactions such as fever, headache, pain at the injection site, and cough after vaccination. For minor adverse reactions after vaccination, there is usually no need to do too much treatment if you are in a good state of mind. After drinking plenty of fluids and resting, the adverse reactions to the vaccine can subside in about 2~3 days on their own. When the low fever leads to mental depression, or other physical discomfort, you can take some appropriate antipyretic way to relieve the symptoms, such as oral ibuprofen under the guidance of the doctor to reduce fever and so on. For the persistence of low fever, it is necessary to go to the regular hospital in time.