Holding urine for a long time will cause a series of effects on the human body, the effects include: 1, long time holding urine will appear in the bladder pressure increases, usually the safe pressure in the bladder is 40cmH2O, such as more than this pressure, it will cause the urine to enter the ureter, into the kidneys, and the emergence of double hydronephrosis, the renal function of the progressive decline. For a longer time, it may cause thinning of the renal cortex, loss of renal function and uremia, affecting the patient’s life and health.2. Prolonged urinary holding will cause the bladder capacity to expand, resulting in proliferation of bladder muscle fibers, and hyperplasia of small atrial trabeculae in the bladder. The bladder forced urethral muscle appears contraction loss of compensation and weak contraction. At this point, bladder power decreases and a neurogenic bladder develops, with the patient experiencing urinary incontinence, dysuria, and an inability to urinate. Surgical treatment is required, or a lifelong cystostomy is needed to treat the condition by wearing a drainage bag to drain the bladder.