Heart transplantation is a treatment for end-stage heart disease, usually for patients with advanced heart disease. Life expectancy will improve after heart transplantation compared to before, but because of a series of complications, the problem of short life expectancy may occur, mainly because of the following reasons: 1, graft rejection: life expectancy of various heart disease end links is greatly shortened, even if heart transplantation is performed, it will face the problem of graft rejection, which may shorten life expectancy to a greater extent than normal; 2, infection: after heart transplantation the donor heart and Self rejection, will take a large number of immunosuppressants, thus causing infection, which will also affect life expectancy; 3, atherosclerosis: isolated heart without innervation, the patient may not have any symptoms, but atherosclerosis will also occur, development, resulting in heart disease, thus affecting life expectancy; 4, other causes: various organs because of immunosuppressants and the impact of the supply heart, will occur a variety of problems These include liver failure, kidney failure, etc., all of which can shorten the life expectancy of transplant patients.