The symptoms of painful urination are likely to be caused by acute urinary tract infection or prostatitis or bladder mucosal lesions, which need to be clarified by further tests, including urine routine, urine culture, prostate fluid routine and cystoscopy. If it is an acute urinary tract infection choose a sensitive antibiotic, such as levofloxacin tablets, ciprofloxacin tablets, treatment for three to five days to get effective relief of symptoms. If the inflammation of the prostate is considered, choose tamsulosin capsules combined with prostate antone tablets and urine retention tablets to get fast and effective relief of symptoms in one to two weeks of treatment. If the problem is found to be a mucosal lesion of the bladder, it is necessary to remove the mucosal lesion through transurethral resection of the bladder in order to get effective and quick relief of the symptoms.