The causes of long walking ankle pain may be fatigue injury, ankle sprain, osteoarthritis and so on. 1. Fatigue injury: walking too much for a long time can make the ankle muscles, cartilage and other soft tissues wear and tear to produce aseptic inflammation, mostly aggravated in the activities, can be improved through rest, local hot compresses. 2. Ankle sprain: long-term bad posture walking may lead to acute ankle sprain, local ligament strain to ankle pain, often accompanied by local redness, swelling and hot pain, etc., through rest, cold compresses, local spray Yunnan Baiyao and other relief. 3. Osteoarthritis: common in the elderly, belonging to the degenerative bone joints, and long time wear and tear of the joints lead to local inflammation, usually need to follow the medical advice to use non-steroidal anti-inflammatory drugs such as ibuprofen extended-release capsule, celecoxib, etc., and when the symptoms are serious, you can also be local hormone closure. When walking for a long time, ankle pain, you need to consult a doctor in time, complete the relevant examination, for the cause of the treatment.