The treatment of tibiofibular fatigue periostitis is usually done in a comprehensive manner as follows. Due to tibiofibular fatigue periostitis, the pathogenesis is mainly due to frequent strenuous activity or cumulative injury of the calf, which causes the muscles of the calf to pull on the periosteum, thus causing exudation at the periosteum and triggering local sterile inflammation. Symptomatic treatment measures should first limit the amount of calf activity, preferably with calf brace immobilization for 2-3 weeks, which can compulsively reduce calf activity, not only can help the inflammatory symptoms subside, thus also can reduce the symptoms of pain. It can also be combined with local warm towel compresses, physiotherapy or the application of Chinese medicine with blood circulation and blood stasis, such as safflower oil or orthopedic water. These drugs can significantly improve the local blood circulation, which is conducive to the remission of inflammation. If the pain is obvious, you can apply Fotarin ointment or directly take Fotarin tablets and other non-steroidal anti-inflammatory drugs orally to promote the remission of inflammation.