Syphilis patients with red dots on the body is mostly considered for the second stage of syphilis, small red dots often refers to syphilis rash, due to the syphilis rash can be manifested in different forms, can mimic a variety of skin diseases rash, so the lack of characterization. Usually the clinical manifestations of the different traits of syphilis rash are not exactly the same, such as maculopapular syphilis rash can be similar to pityriasis rosea, viral rash, diameter of about 0.2-1cm presenting reddish rash. And papular syphilis rash can be manifested as the surface of the crust, flaking, similar to dermatitis, eczema, preferably in the face and limbs and other parts of the face, some patients with syphilis can be localized mucosal ulcers phenomenon. Syphilis is caused by the syphilis spirochete, syphilis rash is often distributed in the local or generalized skin, including palms, soles. Most of the lesions have syphilis spirochetes, and even without treatment, most of the patients can go away on their own in a few weeks. Syphilis rash on the soles of the feet and palms of the hands has the characteristic performance of not blending with each other, similar to collar-like flaking, and the rash is mostly in the size of green beans or soy beans. Syphilis is mainly transmitted through sexual contact, but it can also be transmitted through blood, mother and child. When the patient has the above symptoms or suspects the presence of syphilis, it is recommended to consult a doctor in a timely manner.