Spherical pneumonia is a change in pneumonia described by chest imaging because pneumonia is classified as lobar pneumonia, lobar pneumonia, and mycoplasma pneumonia. Pneumonia manifesting in the shape of a ball is called spherical pneumonia and can be caused by various bacteria and viruses. Cancer belongs to occupying lung lesions, which grows from early nodular to malignant tumors, referring to occupying lung lesions larger than 3 cm, including short burrs, lobar shape, pleural traction sign, pleural depression sign, and even producing pleural effusion, all of which are manifestations of lung cancer. Lung cancer and spherical pneumonia need further differentiation when they are close in size, because lung cancer refers to isolated nodules larger than 3 cm, while single spherical pneumonia is easily confused with this type of lung cancer, and it is easy to differentiate if it is multiple spherical pneumonia. Lung cancer is a malignant change and pneumonia is a patchy, exudative, inflammatory change, which are easily distinguished on imaging. If there is difficulty in differentiation, enhanced chest CT can be performed to see whether the lesion is enhanced and the degree of enhancement to differentiate benign from malignant, while spherical pneumonia is a benign change and lung cancer is a malignant disease.