Diffuse large B-cell lymphoma is the most common type of non-Hodgkin’s lymphoma, which is treated clinically mainly with chemotherapy, combined with radiotherapy and surgery. The specific methods are as follows: 1. Chemotherapy: targeted therapy combined with chemotherapy is the basic treatment, and the current international guidelines recommend Merova combined with CHOP regimen as the standard first-line treatment; for patients in the early stage, 4-6 cycles of chemotherapy can be given; for patients in the advanced stage, 6-8 cycles of chemotherapy should be given; 2. Surgery: for patients in the early stage, the purpose of surgery is to obtain pathology and clarify the diagnosis; for patients with combined For patients with complications, such as gastrointestinal perforation and splenomegaly, resulting in complete blood cell reduction, surgical treatment can serve the purpose of relieving symptoms and removing complications; 3. Radiation therapy: It is a relatively important treatment, and for early diffuse large B-cell lymphoma, local radiation therapy can also be taken after chemotherapy to achieve consolidation and maintenance; 4. Stem cell transplantation: For advanced relapsed refractory high-risk lymphoma, stem cell transplantation is to be taken.