An overview of the treatment of hypoglycemic tolerance

  With the progress of society, the improvement of people’s living standards and the aging of the population, the prevalence of diabetes is increasing year by year, and the majority of people in China have type 2 diabetes, which seriously affects people’s health. So, can type 2 diabetes be prevented?  The development of type 2 diabetes requires a long process. This transitional stage between normal glucose metabolism and diabetes is called “impaired glucose tolerance” (IGT for short). At present, it is widely believed that IGT is the prediabetes stage, and almost all type 2 diabetic patients go through IGT stage before the onset of diabetes, and it is reported abroad that 5-10% of IGT will develop into diabetes each year. If the IGT stage is treated with intervention, it is possible to delay and reduce the transition to diabetes and keep it in the IGT stage or transform it to a normal glucose tolerance state.  IGT cannot be considered a disease at this time, but can develop into a high-risk state for type 2 diabetes and cardiovascular disease. The results of many studies have shown that patients with IGT have not only abnormal glucose metabolism but also other metabolic abnormalities, often accompanied by obesity, elevated serum triglycerides, elevated LDL cholesterol, reduced HDL cholesterol, hyperuricemia, and hyperfibrinogenesis, and therefore, the risk of hypertension and ischemic heart disease in patients with IGT is 15 to 2 times higher than in people with normal glucose tolerance. Therefore, intervention therapy is necessary for people at high risk of diabetes – IGT patients.  1. Dietary control and physical exercise include limiting total caloric intake, reducing dietary fat, especially the content of saturated fatty acids, increasing the proportion of complex carbohydrates and fiber content, quitting smoking, quitting alcohol or reducing alcohol consumption and increasing physical activity, etc., which can help to reduce body weight or maintain normal body weight, enhance insulin sensitivity, reduce hyperinsulinemia, improve glucose tolerance and reduce the risk factors of macrovascular disease .  2.Pharmaceutical intervention therapy Mainly metformin (metformin), α-glucosidase inhibitors and thiazolidinedione derivatives. Metformin improves insulin resistance, reduces intestinal glucose absorption, inhibits hepatic gluconeogenesis, improves glucose tolerance, reduces body weight and blood pressure, and improves lipid metabolism to a certain extent. α-glucosidase inhibitors (Bystolic) slow down intestinal glucose absorption, effectively reduces postprandial glucose, improves insulin resistance, and reduces blood insulin level and blood pressure. Thiazolidinedione derivatives (pioglitazone), as insulin sensitizers, can directly enhance the effect of insulin, lower blood insulin levels and improve glucose tolerance.  IGT is the stage of diabetes mellitus, which can be treated with traditional Chinese medicine according to different conditions of patients and regular review of blood glucose and blood lipid, so as to prevent the change of the disease. The main mechanism is to lower blood glucose, blood lipids (especially free fatty acids) and insulin levels. For those who are obese, most of them belong to phlegm and dampness, so they can take Chinese medicines to strengthen the spleen and remove phlegm and dampness, such as Ginseng and Spleen Pill and Jian Spleen Oral Liquid. If accompanied by constipation can be used senna leaf 10g tea drink. For high blood lipid level, 10g of lotus leaf, 10g of wheat sprout, 10g of raw hawthorn and 30g of grass cassia can be taken in decoction. If accompanied by dark purple lips, tongue with petechiae or numbness of hands and feet, you can take blood plugging tablets, Tongxinluo capsule and other Chinese medicine to activate blood circulation and eliminate blood stasis. If you have Yin deficiency, you can take Liu Wei Di Huang Wan, if you have Yin deficiency, you can take Jin Kui Kidney Qi Wan, if you have Yang deficiency, you can take Jin Kui Kidney Qi Wan, if you have Yang deficiency, you can take Jin Kui Kidney Qi Wan, if you have Yang deficiency, you can take Jin Kui Kidney Qi Wan. For those who have a family history of diabetes and have no clinical symptoms, they can use some herbs that have been proven to have hypoglycemic effects in pharmacological research, such as mulberry bark, corn husk, bitter gourd, yellow lily, kudzu root, and Zhi Mu.