Low plasma fibrin may be caused by primary fibrinogen reduction, secondary hemorrhage and hepatic impairment, etc. It is necessary to clarify the cause of the disease and receive targeted treatment. 1. Primary fibrinogen reduction: such as congenital amaurosis, if there is no adverse symptom, you can regularly review the coagulation function, and supplement fibrinogen if necessary. Eat more protein-rich foods such as eggs and milk. 2. Secondary hemorrhage: such as gastrointestinal bleeding, traumatic bleeding and so on. Fresh plasma or fibrinogen can be infused to correct bleeding, and fibrinogen injection or cold precipitation infusion can be applied. 3. Liver function injury: such as severe hepatitis, cirrhosis, etc., which will lead to a decrease in the ability of the liver to synthesize fibrinogen. It is necessary to actively treat the primary disease, such as glutathione, compound glycyrrhizin to protect the liver treatment, etc., and supplement fibrinogen. If the patient is not feeling well, he should consult the doctor in time, and the use of drugs needs to be carried out under the guidance of the physician.