Drinking too much wine is very harmful to the human body, can lead to gastrointestinal damage, liver damage, alcohol poisoning and even life-threatening. 1. Gastrointestinal damage: wine enters the human body through the mouth, through the esophagus to the gastrointestinal digestive tract, alcohol can directly damage the gastric mucosa, intestinal mucosa, long-term large amount of alcohol consumption can easily lead to gastritis, peptic ulcer, enteritis and other diseases, and can even induce the occurrence of cancer. 2. Liver damage: the main component of alcohol is alcohol, which can be transformed into acetaldehyde and acetic acid after entering the human body, and metabolized by the liver and kidney. Liver is the largest detoxification and metabolism organ in human body, long-term and large amount of alcohol consumption exceeds the metabolism and processing capacity of liver, which can cause alcoholic hepatitis, cirrhosis and even liver cancer. 3. Alcohol poisoning or even life-threatening: Long-term heavy drinking, especially alcoholism, can form alcohol dependence, can also cause alcohol poisoning, which can endanger human life in the long run. If you feel unwell after drinking alcohol, you need to go to the hospital, you can’t just take medication, and it is recommended that you avoid drinking alcohol as much as possible.