The most common cause of elevated r-glutamyl transferase is fatty liver, including alcoholic fatty liver and non-alcoholic fatty liver. However, if the patient’s liver function, transaminases, bilirubin, etc. are also increased in addition to the above indicators, the following possible diseases should be excluded, such as acute hepatitis A, acute hepatitis E, or chronic hepatitis B, hepatitis C, etc. In addition, similar tests may occur for drug-related liver injury. If the patient has alcoholic cirrhosis caused by long-term alcohol consumption, or even liver cancer and other diseases, there will also be an increase in r-glutamyl transferase. It is recommended that the patient should improve the liver and biliary ultrasound or CT, MRI and other tests, combined with liver function tests to clarify the diagnosis.