Beta-1 collagen degradation product is an indicator of bone metabolism and generally represents the degree of bone resorption by osteoclasts. In most cases, β-1 collagen degradation product decreases with age, for example, it is low in women or men after the age of 70 years, and in other cases, the β-1 collagen degradation product is low in patients taking anti-bone resorption drugs, especially bisphosphonates. It is generally not necessary to treat it, but only as a method of monitoring bone metabolism and drug action. Other clinical implications are still being explored and are not conclusive.