Patients who have their blood drawn for hepatitis B DNA, the result is generally less than 500 IU/mL is considered normal, indicating that there is no virus replication. At this time, patients need to be regularly observed, and the hepatitis B system, hepatitis B DNA and liver function should be rechecked every six months or a year to see if the patient has no viral replication. If the patient has a major triple-positive condition, the hepatitis B DNA indicates that the virus has replicated more than 500 IU/mL, and if there is an increase in glutamic acid and glutamic oxalacetic aminotransferase, we should actively consider antiviral treatment. You can choose to actively inject interferon for about six months to a year, some patients may turn negative or turn into carriers. If the patient suggests a small triple-positive, there is generally no viral replication at this time, and the hepatitis B DNA is generally less than 500 IU/mL. For such patients, regular observation is needed and care should be taken not to drink alcohol, stay up late and do not exert yourself. If a patient has a late indication of viral replication, in addition to the option of interferon injections, oral antiviral drugs can also continue to be considered for antiviral treatment. However, once the patient has taken the oral medication, the medication should not be discontinued, as there is a possibility that the patient’s viral replication may rebound after discontinuing the medication, as well as the possibility of a dramatic decline in liver function.