Hepatitis B alkaline phosphatase 161 U/L is high, suggesting that there may be abnormal liver function, bone destruction, cholestasis and other problems, and further tests are needed to confirm the specific condition. Alkaline phosphatase exists in the human liver and bones, as an indicator of liver function tests, usually between 40~150U/L, 161U/L is high, suggesting liver or bone damage, usually due to the chronic erosion of the liver by the hepatitis B virus, and need to do further tests to determine the specific condition. If patients have symptoms such as weight loss, poor sleep quality, loss of appetite, abdominal pain, etc., they should go to the hospital as soon as possible for examination and symptomatic treatment to avoid more serious effects on the body.