Ankle pain in children is associated with diseases such as ankle sprains and fractures, and can also be caused by certain medications. 1.Diseases (1) Trauma: ankle sprain, ankle fracture, talus necrosis, etc. can present ankle pain. (2) Inflammation: Septic arthritis, osteomyelitis, osteoarthritis and other diseases can cause ankle pain. (3) Bone and joint tumor: osteochondroma, sarcoma-like malignant tumor, etc., can cause ankle pain. (2) Drugs: Quinolones may cause inflammation of Achilles tendon and cause ankle pain. 3. Environmental factors: Ankle pain may occur in cold and wet environment. There are many causes of ankle pain, so it is recommended to go to the hospital, identify the cause and treat it promptly.