Hepatitis B virus DNA quantification below the lower limit of detection, generally referred to as hepatitis B virus negative, is good. Hepatitis B virus DNA quantification is mainly used to assess the level of viral replication of hepatitis B infected patients, and is an important indicator for the selection of indications for antiviral therapy and the judgment of efficacy. Generally speaking, ordinary hepatitis B virus DNA quantification less than 100~500IU/ml is normal. If the result of hepatitis B virus DNA quantitative test is lower than the lower limit of detection, it means that the virus replication in the body is weakened, or even no replication. For such patients, it means that the condition is stable, and generally do not need special treatment, regular follow-up can be. If hepatitis B virus DNA quantification below the lower limit of detection is caused by antiviral treatment, it suggests that antiviral treatment has achieved a better therapeutic effect. It is important to note that hepatitis B carriers should follow the doctor’s instructions to regularly review the quantification of hepatitis B virus DNA and combine it with the results of liver function and imaging to determine whether antiviral treatment is needed.