Total protein includes albumin and globulin, if both are low, ulcerative colitis, nephrotic syndrome, hyperthyroidism and other diseases are considered. 1. Ulcerative colitis: the cause of the disease is not clear, it is considered to be related to immunity, genetics, intestinal micro-ecology, etc., and intestinal infections, dietary impurity and other factors can also induce ulcerative colitis. Patients often have abdominal pain, diarrhea, mucus, pus and blood stools and other symptoms, some patients may also be accompanied by loss of appetite, abdominal distension, nausea, etc., can also be manifested as low albumin and globulin. 2. Nephrotic syndrome: the cause of the disease is not completely clear, and is mostly considered to be caused by infection, drugs, genetics, remission and other factors. Usually, patients will have a lot of proteinuria, edema, weight gain and other symptoms, which can be manifested as low albumin and globulin. Some patients may also have hypoproteinemia and hyperlipidemia. 3. Hyperthyroidism: It is usually due to overactive thyroid function, increased synthesis and secretion of thyroid hormone, and is also related to autoimmune disease history, heredity, mental stimulation and other factors. It is associated with a history of autoimmune disease, genetics, mental stimulation, etc. Patients often have symptoms such as fatigue, tachycardia, agitation, etc., accompanied by weight loss, hyperphagia, etc., and low albumin and globulin. In addition to the above, low albumin and globulin may also occur if the patient suffers from chronic malnutrition or liver disease. It is recommended to identify the disease in time and treat it according to the cause.