Crohn’s disease perianal abscess does not heal due to Crohn’s disease causing repeated diarrhea irritation. Crohn’s disease can cause repeated diarrhea, which causes irritation to the anus, when the skin breaks down, it will form an infection and perianal abscesses occur. Due to the recurrent diarrhea, new infections are formed when the perianal abscess breaks down, resulting in a non-healing perianal abscess. The cause of Crohn’s disease is not clear at present, and is usually thought to be related to genetic factors, environmental factors and autoimmune factors. The disease causes cramping pain around the umbilicus or in the right lower abdomen, abdominal ringing, moderate or low-grade fever, and lifelong recurrence in some patients. Crohn’s disease causing non-healing perianal abscesses should be treated aggressively and in accordance with medical advice to avoid exacerbation of the condition.