The first thing to rule out is whether the big toe pain and the flesh pain next to it is caused by shoes that are too thin and cramped, so you can replace them with looser shoes and observe them for a little while. Local trauma to the toe, foot inflammation such as nail fungus, osteomyelitis, gout, bunions, etc. may cause pain in the big toe, so you should consider going to the hospital in time to do the appropriate tests to rule out whether it is caused by the above-mentioned diseases, and then do the appropriate treatment for the cause.