Fasting blood glucose 10.1mmol/L means that fasting blood glucose is very high and needs to be treated quickly to lower blood glucose, otherwise long-term high fasting blood glucose will cause complications or ketoacidosis, first, to use drugs to lower blood glucose, you can use long-acting drugs to lower fasting blood glucose, sulfonylurea hypoglycemic drugs, such as gliclazide, glimepiride, gliquidone, if you have used this drug before You can increase the dose, before using 1 tablet can now use 2 tablets. Second, you can use metformin extended-release tablets, the maximum dose can be up to 2000mg once a day. Third, the use of insulin for treatment, to reduce fasting blood sugar, it is best to use long-acting insulin, that is, bedtime insulin, the use of glycine insulin for symptomatic treatment.