There is no such thing as the fastest pain relief, when the symptoms of toothache need to identify the cause of the disease, may be physiological, there may be pathological; physiological causes can be lifted by adjusting the lifestyle, pathologically induced toothache in the guidance of the doctor to carry out targeted pain relief, such as medication, other treatments and so on. 1. Physiological factors: the patient’s toothache is not necessarily a disease, there may be a daily diet of too hard food caused by dental shock caused by toothache, generally reduce the consumption, adjust the dietary habits of the symptoms will soon be relieved. 2. Pathologic factors: (1) insect tooth: insect tooth is the destruction of tooth tissue and cause dental caries, pulpitis, apical periodontitis, etc., this situation leads to toothache needs to be composite resin filling, root canal treatment. (2) Wisdom tooth pericoronitis: Wisdom tooth pericoronitis refers to the inflammation of the gums around the patient caused by the stimulation of food blockage, food stimulation, calculus, plaque bacteria and other stimuli when the growth of the wisdom tooth is impeded. Typical symptoms include toothache, difficulty in opening mouth, etc. Patients can choose to remove wisdom teeth and take penicillin and other anti-infective drugs to relieve pain under the guidance of doctors. (3) Periodontal abscess: When the periodontitis that the patient originally suffered from develops into an advanced stage, an abscess will be formed, and the patient can choose to take ibuprofen pain medication, abscess incision and drainage, and anti-infection drugs under the guidance of the doctor to relieve pain. If the symptoms of toothache patients are not relieved after lifestyle modification, they should consult a doctor in a timely manner to clarify the cause of the disease and carry out treatment under the guidance of the doctor, and the use of medication should be in accordance with the doctor’s instructions.