In October 2015, the Communist Party’s plenary communiqué allowed for a universal two-child policy. Many mothers and fathers are ready to have a second child. With the rapid development of the economy, the rejuvenation of diseases and the change of people’s concept of child rearing make child rearing not so “casual” as before, everyone wants to have a beautiful, smart and healthy baby, to put it bluntly, the problem of eugenics. The following are some of the preparations I made before giving birth to a second child to friends who are ready to give birth to a second child. The reason should be identified as far as possible if there is a history of bad pregnancy and childbirth in myself or in my family, such as fetal malformation, stillbirth, habitual miscarriage, etc. Women with heart disease, hypertension, chronic nephritis, diabetes mellitus, hyperthyroidism, autoimmune diseases who are planning to become pregnant should determine the current control of the disease and whether they are competent to become pregnant. Those with tuberculosis, syphilis, or acute viral hepatitis should first be actively treated accordingly. Primary infections such as toxoplasmosis, cytomegalovirus, rubella virus, and herpes simplex virus should be treated promptly to obtain protective antibodies before pregnancy. Perform gynecological ultrasound examination before pregnancy to exclude tumors of reproductive organs in order to reduce the occurrence of complications during pregnancy. Change poor lifestyle habits, such as quitting smoking and controlling alcohol consumption. Avoid exposure to toxic substances and be careful with medication if you are sick during pregnancy preparation so that you do not use teratogenic drugs without knowing you are pregnant. Supplementation with folic acid or multivitamins containing folic acid can significantly reduce the risk of neural tube abnormalities, as well as the risk of umbilical bulge and congenital heart disease.