Running causes small blisters on the feet, which are mainly caused by friction. If the blisters are small, they will absorb on their own and do not require special treatment; if the blisters are large, they need to be treated professionally and then antibiotics are used to prevent infection. 1. Smaller blisters: weak blisters caused by friction will be absorbed by the body itself and do not require special treatment, nor do they need to be broken with a needle. 2. Larger blisters: under the guidance of the doctor, the blisters can be pierced with a needle to drain, and then use alcohol or iodine to disinfect the local wound. You can also use some antibiotic ointment locally, such as erythromycin ointment, gentamycin ointment and so on. Because antibiotic ointment can play a role in killing bacteria, so as to achieve the problem of preventing local infection. Finally, then use clean gauze or band-aid bandage can be. Running leads to blisters on the feet is more serious, should go to the hospital in a timely manner, and under the guidance of the doctor for treatment, do not recommend unauthorized treatment to avoid infection.