Which disease is serious, vitiligo or psoriasis, depends on which disease can cause systemic changes. In contrast to psoriasis, vitiligo is a porcelain-white pigmented depigmentation of the face and mucous membranes that can be aesthetically disfiguring, but does not cause systemic or visceral organ involvement. In addition to psoriasis, erythrodermic psoriasis, arthritic psoriasis, and pustular psoriasis can cause liver, kidney, and even joint involvement, resulting in high fever and easy infection, which is more serious than vitiligo.