Vitiligo is a pigment loss disease, the specific pathogenesis of vitiligo is unclear, but after long-term research found that may be related to the following factors: 1, genetic factors: some patients showed familial; 2, mental and neurochemical factors: some vitiligo patients with mental trauma, excessive stress, emotional irritability, some vitiligo patients with white distribution along the nerve distribution; 3, immune factors: some Patients combined with immune diseases, such as systemic lupus erythematosus, in addition to vitiligo blood can be found in many antibodies; 4, melanocyte self-destruction theory: due to immune or other factors, resulting in melanocyte hypofunction or death; 5, reduced copper ion content or tyrosinase deficiency; 6, trauma, sun exposure and other factors.