Painful varicose veins occur due to the formation of thrombosis on the basis of varicose veins, which leads to the formation of thrombotic superficial phlebitis. This is an aseptic inflammatory disease that causes irritation of the skin and subcutaneous tissues due to thrombosis, such as painful skin, increased skin temperature, redness and swelling of the skin, which can be palpated as hard streaks. It is necessary to give some drugs to activate blood circulation and remove blood stasis, such as topical mucopolysaccharide ointment and hesperidin gel, and oral diosmin and mazelite. If necessary, some anticoagulants can be given. The often chosen oral anticoagulants, such as rivaroxaban and apixaban, can enable the patient to recover quickly through this period of treatment.