Physical manifestations: pale face, swollen eyes, face and cheeks: indifferent expression, dementia, dry, thickened, rough and flaky skin all over the body, non-squamous edema, hair loss, yellowish palms of hands and feet, weight gain, thick and brittle nails in a few patients. Neuropsychiatric system: memory loss, mental retardation, drowsiness, slow reaction, anxiety, dizziness, headache, tinnitus, deafness, nystagmus, ataxia, tendon reflexes, Achilles tendon reflexes prolonged, dementia, stiffness, and even lethargy in severe cases. Cardiovascular system: bradycardia, decreased cardiac output, low blood pressure, muffled heart sounds, heart enlargement, may be complicated by coronary artery disease, but generally do not occur angina pectoris and heart failure, sometimes accompanied by pericardial effusion and pleural effusion. Mucous edema cardiomyopathy occurs in severe cases. 4, digestive system: anorexia, abdominal distension, constipation. In severe cases, paralytic intestinal obstruction may occur. Gallbladder contraction is weakened and distended. Half of the patients have gastric acid deficiency, leading to pernicious anemia and iron deficiency anemia. 5, motor system: muscle weakness, pain, ankylosis, can be accompanied by joint lesions such as chronic arthritis. 6, endocrine system: female menorrhagia, amenorrhea, infertility; male impotence, loss of libido. A few patients appear lactation, secondary pituitary enlargement. 7, due to cold, infection, surgery, anesthesia or sedative application of inappropriate stress can be induced by mucous edema coma: manifested as hypothermia (T < 35 ℃), respiratory slowing, bradycardia, blood pressure, limb muscle relaxation, reflexes are weakened or disappeared, and even coma, shock, cardiac and renal failure. 8.Dull small disease: dull expression, mute pronunciation, pale face, periorbital swelling, widening of the distance between the eyes, nasal bridge collapse, thick salivation lips, tongue large outstretched limbs short, duck step. 9, juvenile hypothyroidism: short stature, low intelligence, delayed sexual development.