Degenerative changes in the right knee joint are also known as osteomalacia of the knee and osteoarthritis. It is mostly due to the local osteophytes causing damage to the local cartilage, which leads to the narrowing of the joint space, and synovial congestion, edema, resulting in local intra-articular fluid accumulation and the formation of aseptic inflammation. Pain is the main manifestation, and in severe cases, joint deformation may occur, affecting the normal function of the patient. For early degenerative knee joints, we can pay attention to rest, protection, reduce the amount of exercise, local hot compresses, oral non-steroidal anti-inflammatory drugs and nutritive cartilage drugs, such as ibuprofen extended-release capsules, aminoglucosamine hydrochloride and so on. For the knee degeneration has been very serious, the appearance of inversion or eversion deformity, seriously affecting the patient’s normal walking, activities, it is necessary to actively carry out artificial knee replacement surgery.