Take medicine to eliminate H. pylori, such as rabeprazole, bismuth potassium citrate, metronidazole tablets, and clarithromycin for treatment. Helicobacter pylori is a spiral-shaped, sometimes rod-shaped bacteria that can survive in the strong acidic environment of the stomach and is mainly parasitic in the pyloric area, so it is called H. pylori. Treatment of H. pylori can be done by a combination of three and four company drugs. Stomach acid irritation can lead to chronic gastritis, gastric ulcer, gastroesophageal reflux and aggravate the damage of gastric mucosa. Treatment can be done with proton pump inhibitor, rabeprazole to reduce the secretion of gastric acid. Suppression of gastric acid should be accompanied by bismuth-based drugs, such as bismuth potassium citrate. This is a protective agent for the gastric mucosa and is also able to precipitate in an acidic environment, covering the ulcer surface and promoting ulcer healing. Two or three antibiotics can be chosen. Metronidazole, clarithromycin, and amoxicillin capsules can be used for treatment. Metronidazole belongs to the anti-anaerobic class of drugs, not only can inhibit the growth of anaerobic bacteria, but also can play the role of anti-inflammatory, combined with the inhibition of gastric acid, bismuth drugs can play a role in killing Helicobacter pylori.