The relationship between Crohn’s disease and ankylosing spondylitis is not yet clearly explained clinically, but researchers have found that the two conditions are closely related clinically and belong to the same group of chronic inflammatory diseases. Some patients with ankylosing spondylitis have a combination of Crohn’s disease, which is thought to be a manifestation of ankylosing spondylitis involving the intestines. Ankylosing spondylitis is a chronic inflammatory disease that mainly involves the sacroiliac joints, spine and peripheral joints. The cause of the disease is not yet clear, but studies have shown that it is related to genetic, infectious and immunologic factors. Patients with this disease mainly present with spinal deformity, dull pain in the lumbosacral region and morning stiffness. Crohn’s disease is a type of inflammatory bowel disease, belonging to the chronic granulomatous disease, most commonly found in the end of the ileum and adjacent colon. The main clinical manifestations of the disease are abdominal pain, diarrhea, and in some patients, the formation of abdominal masses or fistulas. Whether it is Crohn’s disease or ankylosing spondylitis, once diagnosed you should actively cooperate with your doctor to avoid further aggravation of the disease, which will cause more harm to the human body.