Cranial defects can result in contusions of brain tissue from minor impact trauma because there is no local protection of the skull and the brain tissue is under the scalp. If the skull defect is bleeding intracranially, it is important to avoid pressure on the location during care, and to avoid touching the skull defect. Attention should also be paid to the expansion of brain tissue at the skull defect. If there is significant outward expansion and high tension, this indicates a significant increase in intracranial pressure and requires the application of dehydrating medication. After skull defect, skull repair should be performed in time to protect the brain tissue and to help the health and aesthetics of the body. Of course, the material used to repair the skull is also very important. With the advancement of medicine, more and more cranial repair materials are becoming available. Plexiglass, light apatite and calcium phosphate cement, which were once used clinically, have been withdrawn from the medical scene due to their poor clinical results. The commonly used material for cranial repair today is titanium mesh, which is also a quality material with a long history of application and better results. However, the metallic properties of titanium mesh often have consequences for patients such as sensitivity to cold and heat reactions and CT image errors. At present, we use PEEK material for skull repair is the early choice of PEEK material for skull repair in China’s expert team, has performed surgery for many patients, including pediatric patients, and through clinical feedback found that PEEK material as a pediatric skull repair material can more accurately restore the patient’s anatomical shape, have better hardness, stability, high biocompatibility, for CT, MR, etc. The surgical approach is more complex and precise than traditional titanium mesh repair.