Hands and feet peeling need to be treated according to the cause of the disease, and the common causes are ringworm, eczema, palmoplantar pustulosis and other diseases. Its treatment includes general treatment, drug treatment and other methods. 1. Tinea versicolor: Tinea versicolor is a superficial fungal infection of the skin caused by dermatophytes invading the hands and feet, mainly through contact infection, manifested as blisters, pimples, vesicles, peeling and other symptoms on the surface of the skin, accompanied by a certain degree of itching, can be used topically with antifungal ointment, such as ketoconazole ointment, terbinafine cream and so on. 2. Eczema: need to choose the topical ointment according to the state of the lesions, if more oozing, need to use boric acid solution first wet compresses, to be oozing to reduce the use of hormonal drugs, such as mometasone furoate cream, glycerine lotion, zinc oxide paste, and so on. If there is no exudation or less exudation, hormonal ointments such as hydrocortisone butyrate can be used directly. 3. Palmoplantar pustulosis: palmoplantar pustulosis may be related to smoking, infection and drugs, manifested as aseptic pustules on the hands and feet, pustules subside around the erythema, desquamation, hyperkeratosis and other symptoms, can be topical glucocorticosteroid ointment, such as halometasone cream, mometasone furoate cream and so on. All of the above drugs have adverse reactions and are recommended to be used under medical supervision. Hands and feet peeling skin may also have other causes, it is recommended to go to the hospital in a timely manner to improve the examination, clear cause to give targeted treatment.