The cause of rough hand skin is usually diseases, such as eczema, tinea cruris, contact dermatitis, etc. Topical medications can relieve the symptoms of the above diseases and do not cause hand roughness. 1. Eczema: is a chronic recurrent skin disease, often lead to red spots on the skin, pimples, scales and other symptoms, can cause hand skin roughness, and accompanied by varying degrees of itching, the need for topical glucocorticoid drug treatment. 2. ringworm: mainly fungal infection caused by skin diseases, often lead to excessive keratinization of the skin on the hands, resulting in rough skin, need to be treated with topical antifungal drugs. 3. Contact dermatitis: it is an inflammatory skin disease caused by skin contact with external substances, such as contact with detergents, chemicals, etc., which can lead to skin roughness, peeling and other symptoms. Rough skin on the hands can go to the dermatology department of the hospital to find out the cause, and follow the doctor’s instructions to use medication.